What is the half-life of 5-Amino-1MQ?

5-Amino-1MQ has a half-life of ~2-4 hours (estimated), which is why it's typically administered Once daily (oral) for optimal therapeutic effect.

How do I reconstitute 5-Amino-1MQ?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Growth Hormone

Preclinical

5-Amino-1MQ

Also known as: 5A1MQ, NNMT Inhibitor

Overview

Key Facts

Primary Goal: A small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in fat tissue that contributes to obesity and metabolic dysfunction

A small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in fat tissue that contributes to obesity and metabolic dysfunction. By blocking NNMT, 5-Amino-1MQ shifts fat cells toward a more metabolically active state, promoting fat loss and improving cellular energy metabolism. Half-Life ~2-4 hours (estimated) Typical Dose 50–150 mg Frequency Once daily (oral) Cycle Length 8-12 weeks on, 4 weeks off

Dosing Information

Half-Life

~2-4 hours (estimated)

Typical Dose

50–150 mg

Frequency

Once daily (oral)

Cycle Length

8-12 weeks on, 4 weeks off

Administration Routes:

subcutaneousoral

Storage & Reconstitution

Unreconstituted (Powder)

Temperature15–25°C (59–77°F)

DurationUp to 3 months

Reconstituted (Mixed)

Temperature15–25°C (59–77°F)

Duration2-4 weeks

Note: Protect from light. Do not freeze reconstituted solution.

Research Summary

Preclinical

Preclinical studies published in Biochemical Pharmacology demonstrated that 5-Amino-1MQ significantly reduced body weight, fat mass, and adipocyte size in diet-induced obesity mouse models without affecting food intake. The compound increased intracellular NAD+ and S-adenosylmethionine (SAM) concentrations. Human clinical trials are pending, but the compound has garnered significant interest in the weight management research community.