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Healing & Recovery
Preclinical

5-Amino-1MQ

5-Amino-1MQ

Also known as: 5A1MQ, NNMT Inhibitor

Overview

Key Facts

Primary Goal: Research and therapeutic applications of 5-Amino-1MQ

Inhibits NNMT enzyme to increase intracellular NAD+ and SAM levels. Promotes shrinkage of adipocytes by activating fat metabolism pathways.

Dosing Information

Half-Life

~2-4 hours (estimated)

Typical Dose

50–150 mg

Frequency

Once daily (oral)

Cycle Length

8-12 weeks on, 4 weeks off

Administration Routes:
subcutaneousoral

Benefits

  • Reduces fat cell size and lipid accumulation
  • Increases NAD+ levels in cells
  • Enhances cellular energy metabolism
  • Supports muscle preservation during fat loss

Side Effects

Mild gastrointestinal discomfortmild
Headachemild
Limited human safety data availablemild

Mechanism of Action

1

Inhibits NNMT enzyme to increase intracellular NAD+ and SAM levels

2

Promotes shrinkage of adipocytes by activating fat metabolism pathways

3

Enhances mitochondrial energy production in muscle and fat tissue

Contraindications

Do not use this peptide if any of the following apply:

  • Liver or kidney disease
  • Pregnancy or breastfeeding
  • Use of medications metabolized by methyltransferase enzymes

Storage & Reconstitution

Unreconstituted (Powder)

Temperature15–25°C (59–77°F)
DurationUp to 3 months

Reconstituted (Mixed)

Temperature15–25°C (59–77°F)
Duration2-4 weeks

Note: Protect from light. Do not freeze reconstituted solution.

Research Summary

Preclinical

Preclinical studies published in Biochemical Pharmacology demonstrated that 5-Amino-1MQ significantly reduced body weight, fat mass, and adipocyte size in diet-induced obesity mouse models without affecting food intake. The compound increased intracellular NAD+ and S-adenosylmethionine (SAM) concentrations. Human clinical trials are pending, but the compound has garnered significant interest in the weight management research community.

Frequently Asked Questions

Common questions about 5-Amino-1MQ

UK-Specific Information

Exclusive data points and guidance for UK residents using 5-Amino-1MQ

UK Lab Testing

UK Lab Testing

Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)

Why this matters: UK-specific lab testing guidance not available on US competitor sites

Commonly Stacked With

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