CJC-1295 (no DAC) / Mod GRF 1-29
CJC-1295 (no DAC) / Mod GRF 1-29
Also known as: Mod GRF 1-29, CJC-1295 without DAC, Modified GRF
Overview
Key Facts
Primary Goal: Research and therapeutic applications of CJC-1295 (no DAC) / Mod GRF 1-29
Activates GHRH receptors on pituitary somatotrophs to trigger acute GH release. Four amino acid substitutions (Ala2, Glu8, Ala15, Leu27) confer DPP-IV resistance.
Dosing Information
of approximately 30 minutes. It produces acute GH pulses that more closely mimic natural physiology.Half-Life~30 minutes
100–300 mcg
1-3 times daily
8-16 weeks
Benefits
- Mimics natural pulsatile GH release pattern
- Enhanced muscle recovery and growth
- Improved sleep quality when dosed before bed
- Synergistic effects when combined with GHRPs
- Lower risk of desensitization compared to DAC variant
Side Effects
Mechanism of Action
Activates GHRH receptors on pituitary somatotrophs to trigger acute GH release
Four amino acid substitutions (Ala2, Glu8, Ala15, Leu27) confer DPP-IV resistance
Works synergistically with ghrelin mimetics by acting on a separate receptor pathway
Contraindications
Do not use this peptide if any of the following apply:
- Active malignancy or history of cancer
- Pregnancy or breastfeeding
- Uncontrolled diabetes
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Mod GRF 1-29 has been shown to produce significant acute GH pulses comparable to native GHRH but with improved metabolic stability. When combined with GHRPs such as ipamorelin, studies show synergistic GH release that can exceed either compound alone by 2-3 fold. It is one of the most commonly used GHRH analogs in peptide research.
Frequently Asked Questions
Common questions about CJC-1295 (no DAC) / Mod GRF 1-29
UK-Specific Information
Exclusive data points and guidance for UK residents using CJC-1295 (no DAC) / Mod GRF 1-29
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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