Cortagen
Cortagen
Also known as: Cortagen tetrapeptide, AEDP
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Cortagen
Penetrates cell nuclei and interacts with specific DNA sequences to regulate gene expression (epigenetic bioregulation model). Modulates expression of genes involved in neuronal survival and synaptic plasticity in the cerebral cortex.
Dosing Information
Short (minutes as intact peptide; epigenetic effects persist)
10–50 mcg
once daily
10-20 days, repeated 2-3 times per year
Benefits
- Potential neuroprotective effects through gene expression modulation
- Supports cerebral cortex function in ageing models
- Epigenetic regulation of neuron-specific gene activity
- Extremely low dose requirement
- Part of the Khavinson bioregulator peptide family with decades of Russian research
Side Effects
Mechanism of Action
Penetrates cell nuclei and interacts with specific DNA sequences to regulate gene expression (epigenetic bioregulation model)
Modulates expression of genes involved in neuronal survival and synaptic plasticity in the cerebral cortex
Part of the cytomaxin/cytogen class of peptide bioregulators hypothesized to restore organ-specific gene expression patterns
Antioxidant effects through upregulation of endogenous antioxidant enzyme expression
Contraindications
Do not use this peptide if any of the following apply:
- Pregnancy or breastfeeding
- Active CNS infections
- Known hypersensitivity to short peptide bioregulators
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Cortagen is part of Professor Khavinson's bioregulator peptide programme, which has produced over 100 published studies on short peptides that modulate gene expression in tissue-specific ways. Research on Cortagen specifically has been published in Russian biomedical journals and the Bulletin of Experimental Biology and Medicine, demonstrating effects on cortical neuron gene expression patterns and neuroprotection in ageing models. The bioregulator hypothesis — that short peptides can epigenetically restore youthful gene expression — remains an active area of research, primarily in Russia and Europe.
Frequently Asked Questions
Common questions about Cortagen
UK-Specific Information
Exclusive data points and guidance for UK residents using Cortagen
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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