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Educational purposes only. Not medical advice. Consult healthcare professionals before use.

Healing & Recovery
Preclinical

Epithalon

Epithalon

Also known as: Epitalon, Epithalone, AGAG, Ala-Glu-Asp-Gly

Overview

Key Facts

Primary Goal: Research and therapeutic applications of Epithalon

Activates telomerase enzyme (hTERT) to extend telomere length. Stimulates pineal gland melatonin production for circadian rhythm regulation.

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Dosing Information

Half-Life

~2-3 hours

Typical Dose

5–10 mg

Frequency

Once daily for 10-20 day cycles

Cycle Length

10-20 days on, 4-6 months off

Administration Routes:
subcutaneousintramuscular

Benefits

  • Activates telomerase to lengthen telomeres
  • Regulates neuroendocrine system and melatonin production
  • Supports immune function and T-cell activity
  • Potential lifespan extension (demonstrated in animal models)
  • Improved sleep quality via pineal gland support

Side Effects

Mild injection site irritationmild
Drowsiness (related to melatonin regulation)mild
Headache (uncommon)mild

Mechanism of Action

1

Activates telomerase enzyme (hTERT) to extend telomere length

2

Stimulates pineal gland melatonin production for circadian rhythm regulation

3

Modulates gene expression related to cellular senescence

4

Enhances antioxidant defence enzymes (SOD, catalase)

Contraindications

Do not use this peptide if any of the following apply:

  • Active cancer (telomerase activation could theoretically promote tumour growth)
  • Autoimmune conditions without medical supervision
  • Pregnancy or breastfeeding

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term
DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)
Duration2-4 weeks

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Research Summary

Preclinical

Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, epithalon has been studied for over 35 years. Animal studies demonstrated a 13.7% increase in lifespan in mice and significant telomere elongation in human cell cultures. A 15-year observational study in elderly patients showed improved immune function, cardiovascular health, and endocrine balance. While promising, large-scale human RCTs are still lacking.

Frequently Asked Questions

Common questions about Epithalon

UK-Specific Information

Exclusive data points and guidance for UK residents using Epithalon

UK Lab Testing

UK Lab Testing

Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)

Why this matters: UK-specific lab testing guidance not available on US competitor sites

Commonly Stacked With

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