Follistatin 344
Follistatin 344
Also known as: FS-344, FST-344, Follistatin
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Follistatin 344
Binds and neutralizes myostatin (GDF-8), the primary negative regulator of muscle mass. Also sequesters activin A and B, removing additional inhibitory signals from muscle growth pathways.
Dosing Information
Not well characterized; estimated several hours for circulating forms
100–300 mcg
Once daily for 10-30 days
10-30 days (short cycles due to limited safety data)
Benefits
- Potent myostatin inhibition leading to muscle hypertrophy
- May increase lean body mass without exercise stimulus
- Potential for muscle wasting disease treatment
- Can enhance recovery from muscle injury
- Reduction in fat mass via improved muscle metabolism
Side Effects
Mechanism of Action
Binds and neutralizes myostatin (GDF-8), the primary negative regulator of muscle mass
Also sequesters activin A and B, removing additional inhibitory signals from muscle growth pathways
Downstream activation of Akt/mTOR signaling promotes protein synthesis
Shifts satellite cell differentiation toward myogenic lineage
Contraindications
Do not use this peptide if any of the following apply:
- Active malignancy (growth factor modulation risk)
- Pregnancy or breastfeeding (activin is critical for reproductive function)
- History of hormone-sensitive cancers
- Pre-existing liver or kidney disease
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Animal studies have demonstrated dramatic increases in muscle mass (up to 100-200% in myostatin-knockout models). A gene therapy trial using AAV-delivered follistatin (NCT01519349) showed increased distance walked in Becker muscular dystrophy patients. The injectable peptide form has limited human clinical data but extensive preclinical evidence supporting its myostatin-inhibiting properties.
Frequently Asked Questions
Common questions about Follistatin 344
UK-Specific Information
Exclusive data points and guidance for UK residents using Follistatin 344
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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