GHK-Cu
GHK-Cu
Also known as: Copper Peptide, GHK Copper, Tripeptide-1 Copper
Overview
Key Facts
Primary Goal: Research and therapeutic applications of GHK-Cu
Delivers bioavailable copper to activate lysyl oxidase for collagen crosslinking. Upregulates TGF-beta signaling to promote extracellular matrix remodeling.
Dosing Information
~1-2 hours (injectable); variable topically
0.5–3 mg
Once daily (topical or injection)
4-8 weeks on, 2-4 weeks off
Benefits
- Stimulates collagen I, III and elastin synthesis
- Reduces fine lines, wrinkles, and photodamage
- Improves skin firmness, thickness, and clarity
- Accelerates wound healing and scar remodeling
- Promotes hair growth and follicle enlargement
- Reduces hyperpigmentation and age spots
Side Effects
Mechanism of Action
Delivers bioavailable copper to activate lysyl oxidase for collagen crosslinking
Upregulates TGF-beta signaling to promote extracellular matrix remodeling
Increases glycosaminoglycan and decorin production for dermal hydration
Modulates metalloproteinase activity to balance collagen turnover
Activates antioxidant genes (SOD, glutathione peroxidase) to combat oxidative skin ageing
Contraindications
Do not use this peptide if any of the following apply:
- Wilson's disease or copper metabolism disorders
- Copper allergy or sensitivity
- Pregnancy or breastfeeding
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Discovered by Dr. Loren Pickart in the 1970s, GHK-Cu has over 100 published studies. Broad Institute Connectivity Map data showed it modulates expression of ~32% of human genes, reversing many age-related expression patterns. Clinical trials demonstrate increased collagen synthesis, improved skin density, and reduced wrinkle depth. It is the most widely adopted peptide in cosmeceutical formulations worldwide.
Frequently Asked Questions
Common questions about GHK-Cu
UK-Specific Information
Exclusive data points and guidance for UK residents using GHK-Cu
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
Commonly Stacked With
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ACE-031
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Acetyl Hexapeptide-3
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AHK-Cu
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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