Gonadorelin
Gonadorelin
Also known as: GnRH, LHRH, Factrel, Lutrelef, Gonadorelin Hydrochloride
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Gonadorelin
Binds GnRH receptors (GnRHR) on anterior pituitary gonadotrophs to stimulate LH and FSH secretion. Pulsatile administration mimics endogenous GnRH pulse generator, maintaining receptor sensitivity.
Dosing Information
2-4 minutes (IV); ~10-40 minutes (SC)
50–200 mcg
2-3 times per week (pulsatile protocols vary)
4-12 weeks in hormone optimization protocols
Benefits
- Stimulates endogenous LH and FSH release
- Supports natural testosterone production without exogenous hormones
- Used diagnostically to assess pituitary gonadotroph function
- May help maintain fertility during TRT or post-cycle recovery
- Preserves natural HPG axis signaling
Side Effects
Mechanism of Action
Binds GnRH receptors (GnRHR) on anterior pituitary gonadotrophs to stimulate LH and FSH secretion
Pulsatile administration mimics endogenous GnRH pulse generator, maintaining receptor sensitivity
Continuous administration (non-pulsatile) causes receptor downregulation and gonadotropin suppression
Contraindications
Do not use this peptide if any of the following apply:
- Hormone-dependent malignancies
- Pregnancy or breastfeeding
- Known hypersensitivity to GnRH or analogs
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Gonadorelin was FDA-approved under the brand names Factrel (for diagnostic use) and Lutrepulse (for pulsatile therapeutic use in hypothalamic amenorrhea). It is the gold-standard diagnostic agent for assessing pituitary GnRH responsiveness. In research and clinical practise, pulsatile gonadorelin has been used to restore fertility in patients with hypothalamic hypogonadism. It has gained renewed interest in the peptide community for maintaining endogenous hormone production alongside testosterone replacement therapy.
Frequently Asked Questions
Common questions about Gonadorelin
UK-Specific Information
Exclusive data points and guidance for UK residents using Gonadorelin
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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