Ipamorelin
Ipamorelin
Also known as: Ipamorelin Acetate, IPA, NNC 26-0161
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Ipamorelin
Selective agonism of GHS-R1a (ghrelin receptor) in the anterior pituitary. Amplifies endogenous GHRH-driven GH pulsatility during slow-wave sleep.
Dosing Information
~2 hours
100–300 mcg
Once daily, 30-60 minutes before bedtime
8-12 weeks on, 4 weeks off
Benefits
- Enhances deep slow-wave sleep duration and quality
- Amplifies the natural nocturnal GH pulse for overnight recovery
- Promotes fat metabolism and lean body composition during sleep
- Supports tissue repair, joint recovery, and collagen synthesis overnight
- Clean GH release profile — does not elevate cortisol or prolactin
- Improves subjective sleep satisfaction and morning energy
Side Effects
Mechanism of Action
Selective agonism of GHS-R1a (ghrelin receptor) in the anterior pituitary
Amplifies endogenous GHRH-driven GH pulsatility during slow-wave sleep
Does not suppress somatostatin, preserving natural GH feedback regulation
Minimal effect on cortisol, prolactin, and aldosterone (high selectivity)
Contraindications
Do not use this peptide if any of the following apply:
- Active cancer or history of malignancy (GH promotes cell proliferation)
- Diabetes — monitor blood glucose (GH can elevate fasting glucose)
- Pregnancy or breastfeeding
- Active pituitary disorders
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Ipamorelin was developed by Novo Nordisk and has been studied in multiple Phase 1 and Phase 2 trials. A key study demonstrated dose-dependent GH release with remarkable selectivity — no significant changes in ACTH, cortisol, prolactin, or TSH at effective GH-releasing doses. Clinical trials for post-surgical ileus (bowel recovery) used IV administration successfully. Sleep-specific research shows that GH secretagogues administered before bedtime increase slow-wave sleep duration by 20-50% in both young and older adults. Ipamorelin's clean side-effect profile makes it the preferred GH peptide for sleep optimisation among researchers and clinicians.
Frequently Asked Questions
Common questions about Ipamorelin
UK-Specific Information
Exclusive data points and guidance for UK residents using Ipamorelin
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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