Lenomorelin (Anamorelin)
Lenomorelin (Anamorelin)
Also known as: Anamorelin, ONO-7643, RC-1291, Adlumiz
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Lenomorelin (Anamorelin)
Selectively agonizes the GHS-R1a (ghrelin) receptor to stimulate GH release and appetite. Activates hypothalamic feeding centers through NPY/AgRP neurons.
Dosing Information
7-12 hours
50–100 mg
once daily, fasted
12-24 weeks (as studied in clinical trials)
Benefits
- Oral administration with convenient dosing
- Clinically proven appetite stimulation in cachectic patients
- Increased lean body mass in cancer cachexia trials
- Elevated GH and IGF-1 levels
- Improved quality of life measures in clinical studies
Side Effects
Mechanism of Action
Selectively agonizes the GHS-R1a (ghrelin) receptor to stimulate GH release and appetite
Activates hypothalamic feeding centres through NPY/AgRP neurons
Promotes positive nitrogen balance and lean mass accretion via GH/IGF-1 axis activation
Contraindications
Do not use this peptide if any of the following apply:
- Significant cardiac conduction disorders (QT prolongation risk)
- Pregnancy or breastfeeding
- Uncontrolled diabetes
- Hepatic impairment
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Anamorelin completed multiple Phase III trials (ROMANA 1, 2, and 3) demonstrating significant increases in lean body mass and body weight in patients with non-small cell lung cancer cachexia. It was approved in Japan in 2021 under the brand name Adlumiz. FDA approval was not pursued after the EMA declined authorization citing improvements in lean mass but insufficient evidence for functional improvement.
Frequently Asked Questions
Common questions about Lenomorelin (Anamorelin)
UK-Specific Information
Exclusive data points and guidance for UK residents using Lenomorelin (Anamorelin)
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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