Melanotan II
Melanotan II
Also known as: MT-2, MT-II, Barbie Drug
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Melanotan II
Activates MC1R to stimulate melanocyte melanin production. Activates MC3R and MC4R in the hypothalamus to modulate sexual arousal and appetite.
Dosing Information
~1-2 hours
250–500 mcg
Once daily during loading, then 1-2 times per week for maintenance
7-14 day loading phase, then maintenance indefinitely or as needed
Benefits
- Rapid and pronounced skin tanning without UV exposure
- Significant pro-erectile effects (originally studied for sexual dysfunction)
- Appetite suppression and modest fat loss
- Enhanced libido in both men and women
- Photoprotective melanin increase
Side Effects
Mechanism of Action
Activates MC1R to stimulate melanocyte melanin production
Activates MC3R and MC4R in the hypothalamus to modulate sexual arousal and appetite
Increases cAMP in melanocytes leading to tyrosinase activation
Crosses the blood-brain barrier to exert central nervous system effects on libido
Contraindications
Do not use this peptide if any of the following apply:
- History of melanoma or dysplastic nevus syndrome
- Cardiovascular disease or uncontrolled hypertension
- Priapism or conditions predisposing to priapism
- Pregnancy or breastfeeding
- Concurrent use of PDE5 inhibitors (increased priapism risk)
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Developed at the University of Arizona in the 1990s, Melanotan II was initially researched for tanning and later for sexual dysfunction. Its pro-erectile effects led to the development of bremelanotide (PT-141), which received FDA approval. MT-II itself remains unregulated and is widely available through research chemical suppliers. Safety concerns centre around mole changes and potential melanoma promotion, though no causal link has been established. Regulatory agencies in Australia and Europe have issued warnings about unregulated use.
Frequently Asked Questions
Common questions about Melanotan II
UK-Specific Information
Exclusive data points and guidance for UK residents using Melanotan II
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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