Melanotan I
Melanotan I
Also known as: MT-1, MT-I, Afamelanotide, Scenesse, CUV1647, [Nle4, D-Phe7]-alpha-MSH
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Melanotan I
Potently and selectively agonizes MC1R on melanocytes, stimulating eumelanin synthesis via cAMP/PKA/MITF pathway. Partial agonism at MC4R contributes to mild pro-sexual and anorexigenic effects.
Dosing Information
~30-50 minutes
500–1000 mcg
once daily during loading, then every 2-3 days
The FDA-approved implant (Scenesse) lasts ~60 days; research protocols vary from 2-4 weeks
Benefits
- FDA-approved (as implant) for erythropoietic protoporphyria (EPP)
- Increases eumelanin production for photoprotective tanning
- More selective melanocortin profile than Melanotan II
- Mild pro-sexual effects through partial MC4R activation
- Potential photoprotective benefit against UV-induced DNA damage
Side Effects
Mechanism of Action
Potently and selectively agonizes MC1R on melanocytes, stimulating eumelanin synthesis via cAMP/PKA/MITF pathway
Partial agonism at MC4R contributes to mild pro-sexual and anorexigenic effects
Norleucine-4 and D-Phe-7 substitutions prevent oxidation and enzymatic degradation, increasing stability over native alpha-MSH
Contraindications
Do not use this peptide if any of the following apply:
- History of melanoma or dysplastic nevus syndrome
- Severe hepatic impairment
- Pregnancy or breastfeeding
- Known hypersensitivity to afamelanotide
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Note: Protect from light. Do not freeze reconstituted solution.
Research Summary
Afamelanotide (Melanotan I) was FDA-approved in October 2019 under the brand name Scenesse as a subcutaneous implant for the prevention of phototoxicity in adults with erythropoietic protoporphyria (EPP). It was previously approved in the EU in 2014. Clinical trials demonstrated significant increases in pain-free time in sunlight. Research has also explored its use in vitiligo, polymorphous light eruption, and actinic keratosis prevention. Its pro-sexual effects are milder than Melanotan II due to greater MC1R selectivity, but MC4R-mediated effects on libido have been documented.
Frequently Asked Questions
Common questions about Melanotan I
UK-Specific Information
Exclusive data points and guidance for UK residents using Melanotan I
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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