Melanotan II
Melanotan II
Also known as: MT-2, MT-II, Melanotan 2
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Melanotan II
Non-selectively agonizes melanocortin receptors MC1R (skin pigmentation), MC3R and MC4R (sexual function and energy homeostasis), and MC5R. MC1R activation stimulates melanogenesis in melanocytes, increasing eumelanin production.
Dosing Information
~1 hour
250–1000 mcg
initially daily for loading, then 1-2 times weekly for maintenance
Loading phase of 1-2 weeks, then ongoing maintenance as needed
Benefits
- Promotes significant skin tanning without UV exposure
- Notable pro-sexual effects including enhanced libido and spontaneous erections
- Moderate appetite suppression and potential fat loss
- Cross-functional effects on both tanning and sexual function
Side Effects
Mechanism of Action
Non-selectively agonizes melanocortin receptors MC1R (skin pigmentation), MC3R and MC4R (sexual function and energy homeostasis), and MC5R
MC1R activation stimulates melanogenesis in melanocytes, increasing eumelanin production
MC4R activation in hypothalamic and limbic circuits enhances sexual arousal and desire
MC3R/MC4R activity in hypothalamic feeding centres contributes to appetite suppression
Contraindications
Do not use this peptide if any of the following apply:
- History of melanoma or atypical mole syndrome
- Cardiovascular disease or uncontrolled hypertension
- Pregnancy or breastfeeding
- Autoimmune conditions affecting skin pigmentation
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Note: Protect from light. Do not freeze reconstituted solution.
Research Summary
Melanotan II was developed at the University of Arizona in the early 1990s as a photoprotective tanning agent. Phase I/II trials demonstrated effective tanning without UV exposure and revealed unexpected pro-sexual side effects, prompting development of the more selective PT-141. Due to its non-selective melanocortin activation and safety concerns around mole changes and melanoma risk, it has not pursued regulatory approval, though it remains widely available in research settings.
Frequently Asked Questions
Common questions about Melanotan II
UK-Specific Information
Exclusive data points and guidance for UK residents using Melanotan II
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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