MGF
MGF
Also known as: Mechano Growth Factor, IGF-1Ec, MGF peptide
Overview
Key Facts
Primary Goal: Research and therapeutic applications of MGF
Unique E-domain peptide activates quiescent satellite (stem) cells in damaged muscle. Initiates satellite cell proliferation before they differentiate (priming phase).
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Compare MGF prices →Dosing Information
5-7 minutes (extremely short, rapidly degraded by proteases)
100–400 mcg
Immediately post-workout, bilaterally into trained muscle groups
4-5 weeks
Benefits
- Activates dormant satellite cells to initiate muscle repair
- Promotes local muscle-specific hypertrophy at injection site
- Complements the later-acting systemic IGF-1 isoforms
- May enhance recovery from acute muscle injury
- Does not significantly impact systemic IGF-1 or insulin levels
Side Effects
Mechanism of Action
Unique E-domain peptide activates quiescent satellite (stem) cells in damaged muscle
Initiates satellite cell proliferation before they differentiate (priming phase)
Acts in an autocrine/paracrine manner within mechanically stressed muscle tissue
Signals through the IGF-1 receptor but with distinct downstream signaling kinetics due to E-domain
Contraindications
Do not use this peptide if any of the following apply:
- Active malignancy
- Pregnancy or breastfeeding
- Acute muscle tears (may worsen inflammation acutely)
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
For suppliers & labs
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Research Summary
MGF was discovered by Dr. Geoffrey Goldspink's group at University College London. Research demonstrated that mechanical overload induces MGF expression as the initial IGF-1 splice variant before shifting to IGF-1Ea (systemic). Animal studies show MGF administration increases muscle mass by 20% within weeks. The extremely short half-life of the synthetic peptide limits practical use, leading to the development of PEG-MGF for extended activity.
Frequently Asked Questions
Common questions about MGF
UK-Specific Information
Exclusive data points and guidance for UK residents using MGF
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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