MOTS-c
MOTS-c
Also known as: MOTS-c peptide, Mitochondrial-Derived Peptide
Overview
Key Facts
Primary Goal: Research and therapeutic applications of MOTS-c
Activates AMPK pathway to promote cellular energy metabolism. Enhances glucose uptake in skeletal muscle independent of insulin.
Dosing Information
~4-6 hours (estimated)
5–10 mg
3-5 times per week
4-8 weeks on, 4 weeks off
Benefits
- Enhances fatty acid oxidation and metabolic rate
- Improves insulin sensitivity and glucose uptake
- Boosts exercise capacity and endurance
- Supports healthy mitochondrial function
- Potential anti-ageing metabolic benefits
Side Effects
Mechanism of Action
Activates AMPK pathway to promote cellular energy metabolism
Enhances glucose uptake in skeletal muscle independent of insulin
Regulates mitochondrial biogenesis and function
Modulates the folate-methionine cycle affecting cellular metabolism
Contraindications
Do not use this peptide if any of the following apply:
- Hypoglycemia or use of insulin-sensitizing drugs without monitoring
- Pregnancy or breastfeeding
- Severe metabolic disorders without medical supervision
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Discovered by Dr. Pinchas Cohen's lab at USC, MOTS-c has shown in animal studies to improve metabolic homeostasis, enhance exercise capacity, and protect against age-related metabolic decline. It activates AMPK in skeletal muscle, promoting glucose metabolism. Human observational studies correlate higher endogenous MOTS-c levels with better metabolic health. Clinical trials in humans are still in early stages.
Frequently Asked Questions
Common questions about MOTS-c
UK-Specific Information
Exclusive data points and guidance for UK residents using MOTS-c
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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