Semaglutide
Semaglutide
Also known as: Ozempic, Wegovy, GLP-1
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Semaglutide
Activates GLP-1 receptors in the hypothalamus to reduce appetite. Delays gastric emptying to promote satiety.
Dosing Information
~7 days
0.25–2.4 mg
Once weekly
Ongoing / indefinite under medical supervision
Benefits
- Significant sustained weight loss (up to 15-17% body weight)
- Improved glycemic control and insulin sensitivity
- Reduced cardiovascular risk markers
- Decreased appetite and food cravings
- Improved blood pressure and lipid profiles
Side Effects
Mechanism of Action
Activates GLP-1 receptors in the hypothalamus to reduce appetite
Delays gastric emptying to promote satiety
Enhances glucose-dependent insulin secretion from pancreatic beta cells
Suppresses glucagon release to improve blood sugar regulation
Contraindications
Do not use this peptide if any of the following apply:
- Personal or family history of medullary thyroid carcinoma
- Multiple endocrine neoplasia syndrome type 2 (MEN2)
- History of pancreatitis
- Severe gastrointestinal disease
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
The STEP clinical trial programme demonstrated that semaglutide 2.4 mg weekly produces an average weight loss of approximately 15% of body weight over 68 weeks. The SELECT trial further showed a 20% reduction in major adverse cardiovascular events. FDA-approved for chronic weight management in adults with BMI ≥30 or ≥27 with at least one weight-related comorbidity.
Frequently Asked Questions
Common questions about Semaglutide
UK-Specific Information
Exclusive data points and guidance for UK residents using Semaglutide
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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