What is the half-life of SLU-PP-332?

SLU-PP-332 has a half-life of Unknown, which is why it's typically administered As needed for optimal therapeutic effect.

How do I reconstitute SLU-PP-332?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

What is the half-life of SLU-PP-332?

SLU-PP-332 has a half-life of Unknown, which is why it's typically administered As needed for optimal therapeutic effect.

How do I reconstitute SLU-PP-332?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Healing & Recovery

Preclinical

SLU-PP-332

Also known as: SLUPP332, SLU PP 332, ERRγ agonist, exercise mimetic

Overview

Key Facts

Primary Goal: Research and therapeutic applications of SLU-PP-332

Selectively activates estrogen-related receptor gamma (ERRγ) in skeletal muscle. Upregulates genes involved in mitochondrial biogenesis and oxidative phosphorylation.

Dosing Information

Half-Life

~4-6 hours (estimated from animal pharmacokinetic data)

Typical Dose

10–50 mg

Frequency

Once daily (research dosing, not established for humans)

Cycle Length

4-8 weeks (based on animal study durations)

Administration Routes:

subcutaneousoral

Benefits

Mimics exercise-induced metabolic adaptations without physical activity
Promotes shift toward slow-twitch (type I) oxidative muscle fibres
Enhances mitochondrial biogenesis and oxidative capacity
Increases fat oxidation and energy expenditure
Improves exercise endurance and fatigue resistance
May protect against obesity and metabolic dysfunction

Side Effects

Limited human safety data (preclinical compound)uncommonmild

Potential hormonal interactions via estrogen-related receptor pathwaysuncommonmild

Unknown long-term effects on muscle and metabolismuncommonmild

Possible gastrointestinal discomfortuncommonmild

Risk of unintended gene expression changesuncommonmild

Mechanism of Action

Selectively activates estrogen-related receptor gamma (ERRγ) in skeletal muscle

Upregulates genes involved in mitochondrial biogenesis and oxidative phosphorylation

Promotes type I (slow-twitch) muscle fibre gene expression programs

Enhances fatty acid oxidation pathways similar to endurance exercise adaptations

Activates PGC-1α-related transcriptional programs for metabolic remodeling

Contraindications

Do not use this peptide if any of the following apply:

Not approved for human use — research compound only
Pregnancy or breastfeeding
Hormone-sensitive conditions
Unknown drug interactions
Pre-existing liver or kidney conditions (no human safety data)

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Note: Protect from light. Do not freeze reconstituted solution.

Research Summary

Preclinical

Developed by Dr. Thomas Bhurrows lab at Saint Louis University, SLU-PP-332 was published in 2023 showing it activates ERRγ to replicate key metabolic benefits of exercise in mouse models. Treated mice showed increased slow-twitch muscle fibres, enhanced endurance capacity, and resistance to diet-induced obesity without changes in physical activity. The compound represents a new class of exercise mimetics targeting nuclear hormone receptors rather than traditional peptide pathways. Still in early preclinical stages with no human clinical trials initiated.

Frequently Asked Questions

Common questions about SLU-PP-332

UK-Specific Information

Exclusive data points and guidance for UK residents using SLU-PP-332

UK Lab Testing

Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)

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