Survodutide
Survodutide
Also known as: BI 456906, BI456906
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Survodutide
GLP-1 receptor agonism reduces appetite and improves glycemic control. Glucagon receptor agonism increases hepatic fat oxidation and energy expenditure.
Dosing Information
~5-6 days
0.3–6 mg
Once weekly
Ongoing / indefinite under medical supervision
Benefits
- Significant weight loss (up to 19% in Phase 2)
- Potent liver fat reduction and MASH resolution
- Improved hepatic and metabolic health markers
- Increased energy expenditure via glucagon signaling
Side Effects
Mechanism of Action
GLP-1 receptor agonism reduces appetite and improves glycemic control
Glucagon receptor agonism increases hepatic fat oxidation and energy expenditure
Dual action promotes negative energy balance through complementary pathways
Contraindications
Do not use this peptide if any of the following apply:
- Personal or family history of medullary thyroid carcinoma
- MEN2 syndrome
- Severe hepatic impairment
- History of pancreatitis
- Pregnancy or breastfeeding
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Phase 2 data showed survodutide produced up to 18.7% weight loss at 46 weeks and significant improvements in MASH histological endpoints, including fibrosis. The compound demonstrated 83% relative reduction in liver fat content. Phase 3 trials are ongoing for both obesity and MASH indications. Boehringer Ingelheim positions survodutide as a liver-focused metabolic therapy with strong weight loss as a co-benefit.
Frequently Asked Questions
Common questions about Survodutide
UK-Specific Information
Exclusive data points and guidance for UK residents using Survodutide
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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