What is the half-life of TB-500 (Immune)?

TB-500 (Immune) has a half-life of Unknown, which is why it's typically administered As needed for optimal therapeutic effect.

How do I reconstitute TB-500 (Immune)?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

What is the half-life of TB-500 (Immune)?

TB-500 (Immune) has a half-life of Unknown, which is why it's typically administered As needed for optimal therapeutic effect.

How do I reconstitute TB-500 (Immune)?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Healing & Recovery

Preclinical

TB-500 (Immune)

Also known as: TB4, Thymosin Beta-4, Tβ4

Overview

Key Facts

Primary Goal: Research and therapeutic applications of TB-500 (Immune)

Sequesters G-actin to regulate immune cell cytoskeletal dynamics. Downregulates NF-kB-mediated pro-inflammatory signaling.

Dosing Information

Half-Life

~2 hours

Typical Dose

2–5 mg

Frequency

2x per week (loading), 1x per week (maintenance)

Cycle Length

4-8 weeks loading, then maintenance

Administration Routes:

subcutaneousintramuscular

Benefits

Modulates inflammatory immune responses
Promotes immune cell migration to sites of infection or injury
Reduces excessive inflammatory cytokine production
Supports thymic function and T-cell development
Anti-fibrotic effects reduce immune-mediated tissue damage
Promotes tissue repair following immune-mediated injury

Side Effects

Temporary lethargyuncommonmild

Head rush shortly after injectionuncommonmild

Injection site rednessuncommonmild

Mild flu-like symptoms during loading phaseuncommonmild

Mechanism of Action

Sequesters G-actin to regulate immune cell cytoskeletal dynamics

Downregulates NF-kB-mediated pro-inflammatory signaling

Modulates macrophage polarization toward anti-inflammatory M2 phenotype

Promotes T-regulatory cell activity

Reduces TNF-alpha and IL-1-beta production in activated immune cells

Contraindications

Do not use this peptide if any of the following apply:

Active cancer (promotes angiogenesis)
Pregnancy or breastfeeding
Active severe infections (theoretical immune modulation)

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-3 weeks

Research Summary

Preclinical

Thymosin Beta-4 was originally isolated from the thymus and has well-documented immune-modulatory properties alongside its healing effects. Clinical trials by RegeneRx Biopharmaceuticals have explored its role in wound healing and tissue repair, with immune modulation being a key secondary mechanism. Cross-reference: see tb-500 in healing-recovery for full tissue repair profile.

Frequently Asked Questions

Common questions about TB-500 (Immune)

UK-Specific Information

Exclusive data points and guidance for UK residents using TB-500 (Immune)

UK Lab Testing

Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)

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