Tesamorelin
Tesamorelin
Also known as: Egrifta, TH9507
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Tesamorelin
Activates GHRH receptors on the anterior pituitary to stimulate endogenous GH secretion. Trans-3-hexenoic acid group enhances resistance to enzymatic degradation.
Dosing Information
26-38 minutes
1000–2000 mcg
once daily
26 weeks (per FDA labeling), ongoing as prescribed
Benefits
- FDA-approved for visceral adipose tissue reduction
- Significant reduction in trunk fat in clinical trials
- Improved IGF-1 levels
- May improve lipid profiles (triglycerides, cholesterol)
- Potential cognitive benefits shown in Alzheimer's research
Side Effects
Mechanism of Action
Activates GHRH receptors on the anterior pituitary to stimulate endogenous GH secretion
Trans-3-hexenoic acid group enhances resistance to enzymatic degradation
Increased GH and IGF-1 promote lipolysis, particularly in visceral adipose tissue
Contraindications
Do not use this peptide if any of the following apply:
- Active malignancy or disruption of the hypothalamic-pituitary axis from tumour or surgery
- Pregnancy (Category X)
- Known hypersensitivity to tesamorelin or mannitol
- Pituitary gland surgery or irradiation
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Tesamorelin received FDA approval in 2010 for HIV-associated lipodystrophy. Phase III trials demonstrated an average 15-18% reduction in visceral adipose tissue over 26 weeks. More recent research has explored its potential cognitive benefits, with a 2020 study showing improvements in executive function and verbal memory in adults at risk for Alzheimer's disease.
Frequently Asked Questions
Common questions about Tesamorelin
UK-Specific Information
Exclusive data points and guidance for UK residents using Tesamorelin
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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