What is the half-life of ARA-290?

ARA-290 has a half-life of ~2 minutes (rapid clearance, prolonged tissue effects), which is why it's typically administered 1x daily for optimal therapeutic effect.

How do I reconstitute ARA-290?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Healing & Recovery

Phase 3

ARA-290

Also known as: Cibinetide, Helix B Surface Peptide, HBSP

Overview

Key Facts

Primary Goal: An 11-amino acid synthetic peptide derived from the B helix of erythropoietin

An 11-amino acid synthetic peptide derived from the B helix of erythropoietin. Selectively activates the innate repair receptor (IRR) to promote tissue protection and repair without erythropoietic (blood cell) stimulation. Half-Life ~2 minutes (rapid clearance, prolonged tissue effects) Typical Dose 2–4 mg Frequency 1x daily Cycle Length 4-12 weeks

Dosing Information

Half-Life

~2 minutes (rapid clearance, prolonged tissue effects)

Typical Dose

2–4 mg

Frequency

1x daily

Cycle Length

4-12 weeks

Administration Routes:

subcutaneousintravenous

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration1 week

Research Summary

Phase 3

Multiple Phase 2 clinical trials completed for sarcoidosis-associated neuropathy and diabetic neuropathic pain. Demonstrated improved corneal nerve fiber density and reduced neuropathic symptoms. Developed by Araim Pharmaceuticals with promising safety and tolerability data.