What is the half-life of Carnosine?

Carnosine has a half-life of ~9 minutes in plasma (rapidly degraded by carnosinase); tissue levels persist longer, which is why it's typically administered Twice daily (oral) for optimal therapeutic effect.

How do I reconstitute Carnosine?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Anti-Ageing

Preclinical

Carnosine

Also known as: L-Carnosine, Beta-alanyl-histidine, Carcinine precursor

Overview

Key Facts

Primary Goal: A naturally occurring dipeptide composed of beta-alanine and histidine, found in high concentrations in muscle and brain tissue

A naturally occurring dipeptide composed of beta-alanine and histidine, found in high concentrations in muscle and brain tissue. Carnosine is a potent anti-glycation agent that prevents the formation of advanced glycation end products (AGEs) — a major contributor to aging, diabetes complications, and neurodegenerative disease. Half-Life ~9 minutes in plasma (rapidly degraded by carnosinase); tissue levels persist longer Typical Dose 500–1000 mg Frequency Twice daily (oral) Cycle Length Continuous supplementation or 8-12 week cycles

Dosing Information

Half-Life

~9 minutes in plasma (rapidly degraded by carnosinase); tissue levels persist longer

Typical Dose

500–1000 mg

Frequency

Twice daily (oral)

Cycle Length

Continuous supplementation or 8-12 week cycles

Administration Routes:

oraltopical

Storage & Reconstitution

Unreconstituted (Powder)

Temperature15–25°C (59–77°F)

DurationUp to 3 months

Reconstituted (Mixed)

Temperature15–25°C (59–77°F)

Duration2-4 weeks

Research Summary

Preclinical

Carnosine has been extensively studied with hundreds of peer-reviewed publications. Human trials have shown benefits for glycemic control in prediabetic and diabetic patients, cognitive function in elderly populations, and exercise performance. A key study in the British Journal of Nutrition demonstrated that 2g/day of carnosine improved glycemic control and reduced AGE levels. Research by Hipkiss and others has established carnosine as one of the most effective natural anti-glycation agents. Its short plasma half-life (due to serum carnosinase) has led to interest in sustained-release formulations.