What is the half-life of CJC-1295 (with DAC)?

CJC-1295 (with DAC) has a half-life of 6-8 days, which is why it's typically administered 1-2 times per week for optimal therapeutic effect.

How do I reconstitute CJC-1295 (with DAC)?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Growth Hormone

Phase 2

CJC-1295 (with DAC)

Also known as: CJC-1295 DAC, DAC:GRF

Overview

Key Facts

Primary Goal: A modified growth hormone releasing hormone (GHRH) analog with a Drug Affinity Complex that binds to albumin, extending its half-life to approximately 6-8 days

A modified growth hormone releasing hormone (GHRH) analog with a Drug Affinity Complex that binds to albumin, extending its half-life to approximately 6-8 days. This allows for sustained GH elevation with less frequent dosing compared to non-DAC variants. Half-Life 6-8 days Typical Dose 1000–2000 mcg Frequency 1-2 times per week Cycle Length 8-12 weeks

Dosing Information

Half-Life

6-8 days

Typical Dose

1000–2000 mcg

Frequency

1-2 times per week

Cycle Length

8-12 weeks

Administration Routes:

subcutaneous

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Research Summary

Phase 2

CJC-1295 with DAC has been studied in Phase II clinical trials demonstrating dose-dependent increases in GH and IGF-1 levels sustained over weeks. Research showed 2-10 fold increases in mean GH concentrations after a single injection. Development was paused due to safety concerns in one trial, though the compound remains widely studied in research settings.