What is the half-life of Epithalon?

Epithalon has a half-life of ~2-3 hours, which is why it's typically administered Once daily for 10-20 day cycles for optimal therapeutic effect.

How do I reconstitute Epithalon?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Anti-Ageing

Preclinical

Epithalon

Also known as: Epitalon, Epithalone, AGAG, Ala-Glu-Asp-Gly

Overview

Key Facts

Primary Goal: A synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural peptide epithalamin produced by the pineal gland

A synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural peptide epithalamin produced by the pineal gland. Epithalon is one of the most studied anti-aging peptides, primarily researched for its ability to activate telomerase and thereby elongate telomeres — the protective caps on chromosomes that shorten with age. Half-Life ~2-3 hours Typical Dose 5–10 mg Frequency Once daily for 10-20 day cycles Cycle Length 10-20 days on, 4-6 months off

Dosing Information

Half-Life

~2-3 hours

Typical Dose

5–10 mg

Frequency

Once daily for 10-20 day cycles

Cycle Length

10-20 days on, 4-6 months off

Administration Routes:

subcutaneousintramuscular

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Research Summary

Preclinical

Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, epithalon has been studied for over 35 years. Animal studies demonstrated a 13.7% increase in lifespan in mice and significant telomere elongation in human cell cultures. A 15-year observational study in elderly patients showed improved immune function, cardiovascular health, and endocrine balance. While promising, large-scale human RCTs are still lacking.