What is the half-life of GHK-Cu?

GHK-Cu has a half-life of ~1-2 hours (injectable); variable topically, which is why it's typically administered Once daily (topical or injection) for optimal therapeutic effect.

How do I reconstitute GHK-Cu?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Healing & Recovery

Preclinical

GHK-Cu

Also known as: Copper Peptide, GHK Copper, Tripeptide-1 Copper

Overview

Key Facts

Primary Goal: A naturally occurring copper-binding tripeptide present in human plasma, saliva, and urine

A naturally occurring copper-binding tripeptide present in human plasma, saliva, and urine. GHK-Cu declines with age and is one of the most studied cosmetic peptides, renowned for stimulating collagen synthesis, improving skin elasticity, reducing fine lines, and promoting hair follicle health. It is a staple ingredient in high-end skincare formulations. Half-Life ~1-2 hours (injectable); variable topically Typical Dose 0.5–3 mg Frequency Once daily (topical or injection) Cycle Length 4-8 weeks on, 2-4 weeks off

Dosing Information

Half-Life

~1-2 hours (injectable); variable topically

Typical Dose

0.5–3 mg

Frequency

Once daily (topical or injection)

Cycle Length

4-8 weeks on, 2-4 weeks off

Administration Routes:

subcutaneoustopical

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F)

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Research Summary

Preclinical

100 studies

Discovered by Dr. Loren Pickart in the 1970s, GHK-Cu has over 100 published studies. Broad Institute Connectivity Map data showed it modulates expression of ~32% of human genes, reversing many age-related expression patterns. Clinical trials demonstrate increased collagen synthesis, improved skin density, and reduced wrinkle depth. It is the most widely adopted peptide in cosmeceutical formulations worldwide.