What is the half-life of IGF-1 DES?

IGF-1 DES has a half-life of 20-30 minutes, which is why it's typically administered Pre-workout or immediately mail-workout, bilaterally into target muscle for optimal therapeutic effect.

How do I reconstitute IGF-1 DES?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Muscle Growth

Preclinical

IGF-1 DES

Also known as: DES IGF-1, IGF-1 DES(1-3), Truncated IGF-1

Overview

Key Facts

Primary Goal: A truncated form of IGF-1 lacking the first three N-terminal amino acids (Gly-Pro-Glu)

A truncated form of IGF-1 lacking the first three N-terminal amino acids (Gly-Pro-Glu). This modification eliminates binding to most IGF binding proteins, making it approximately 10 times more potent than native IGF-1 at the receptor level. Its extremely short half-life makes it ideal for targeted, site-specific intramuscular injections to promote localized muscle growth. Half-Life 20-30 minutes Typical Dose 20–80 mcg Frequency Pre-workout or immediately mail-workout, bilaterally into target muscle Cycle Length 4-6 weeks on, 2-4 weeks off

Dosing Information

Half-Life

20-30 minutes

Typical Dose

20–80 mcg

Frequency

Pre-workout or immediately post-workout, bilaterally into target muscle

Cycle Length

4-6 weeks on, 2-4 weeks off

Administration Routes:

intramuscular

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Research Summary

Preclinical

Des(1-3) IGF-1 was originally identified as a naturally occurring brain IGF-1 variant. In vitro studies demonstrate 5-10x greater mitogenic potency than full-length IGF-1 in myoblast cultures. Animal studies confirm enhanced muscle protein synthesis with local administration. Research in dairy cattle showed significant mammary growth effects. It remains a research compound with no clinical trials in humans for muscle indications.