What is the half-life of Kisspeptin-10?

Kisspeptin-10 has a half-life of ~4 minutes (IV bolus); ~28 minutes (SC), which is why it's typically administered single dose or pulsatile infusion in research protocols for optimal therapeutic effect.

How do I reconstitute Kisspeptin-10?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Healing & Recovery

Phase 1

Kisspeptin-10

Also known as: KP-10, Metastin 45-54, Kisspeptin

Overview

Key Facts

Primary Goal: A 10-amino acid C-terminal fragment of the kisspeptin family that is a potent agonist of the GPR54 (KISS1R) receptor

A 10-amino acid C-terminal fragment of the kisspeptin family that is a potent agonist of the GPR54 (KISS1R) receptor. Kisspeptin is a master regulator of the hypothalamic-pituitary-gonadal (HPG) axis and plays a critical role in puberty onset, reproductive hormone secretion, and sexual behavior. Half-Life ~4 minutes (IV bolus); ~28 minutes (SC) Typical Dose 1–10 mcg Frequency single dose or pulsatile infusion in research protocols Cycle Length Research protocols vary; typically acute or short-term dosing

Dosing Information

Half-Life

~4 minutes (IV bolus); ~28 minutes (SC)

Typical Dose

1–10 mcg

Frequency

single dose or pulsatile infusion in research protocols

Cycle Length

Research protocols vary; typically acute or short-term dosing

Administration Routes:

subcutaneousintravenous

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Research Summary

Phase 1

Kisspeptin-10 has been studied in multiple Phase I/II clinical trials at Imperial College London and other institutions. Research demonstrates it potently stimulates LH secretion in healthy volunteers and can restore reproductive hormone pulsatility in women with hypothalamic amenorrhea. Functional MRI studies have shown kisspeptin enhances brain processing of sexual and romantic stimuli, suggesting a role beyond pure endocrine regulation. It is being investigated as a potential therapeutic for infertility and low sexual desire.