What is the half-life of Liraglutide?

Liraglutide has a half-life of ~13 hours, which is why it's typically administered Once daily for optimal therapeutic effect.

How do I reconstitute Liraglutide?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Growth Hormone

Approved

Liraglutide

Also known as: Saxenda, Victoza, NN2211

Overview

Key Facts

Primary Goal: A GLP-1 receptor agonist and one of the first FDA-approved injectable medications specifically for chronic weight management

A GLP-1 receptor agonist and one of the first FDA-approved injectable medications specifically for chronic weight management. While it requires daily dosing and produces less weight loss than newer agents, liraglutide has an extensive safety track record and remains widely used. Half-Life ~13 hours Typical Dose 0.6–3 mg Frequency Once daily Cycle Length Ongoing / indefinite under medical supervision

Dosing Information

Half-Life

~13 hours

Typical Dose

0.6–3 mg

Frequency

Once daily

Cycle Length

Ongoing / indefinite under medical supervision

Administration Routes:

subcutaneous

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F)

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Research Summary

Approved

The SCALE trial program demonstrated that liraglutide 3.0 mg daily produces an average weight loss of approximately 8% over 56 weeks. The LEADER cardiovascular outcomes trial showed a 13% reduction in MACE events. One of the earliest GLP-1 agents approved for weight management, with over a decade of mail-marketing safety data.