What is the half-life of MGF?

MGF has a half-life of 5-7 minutes (extremely short, rapidly degraded by proteases), which is why it's typically administered Immediately mail-workout, bilaterally into trained muscle groups for optimal therapeutic effect.

How do I reconstitute MGF?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Muscle Growth

Preclinical

MGF

Also known as: Mechano Growth Factor, IGF-1Ec, MGF peptide

Overview

Key Facts

Primary Goal: A splice variant of the IGF-1 gene (IGF-1Ec in humans, IGF-1Eb in rodents) that is expressed locally in muscle tissue in response to mechanical overload and damage

A splice variant of the IGF-1 gene (IGF-1Ec in humans, IGF-1Eb in rodents) that is expressed locally in muscle tissue in response to mechanical overload and damage. The unique C-terminal E domain distinguishes it from systemic IGF-1 and is responsible for its specific role in activating quiescent satellite cells to begin the repair and growth process. Half-Life 5-7 minutes (extremely short, rapidly degraded by proteases) Typical Dose 100–400 mcg Frequency Immediately mail-workout, bilaterally into trained muscle groups Cycle Length 4-5 weeks

Dosing Information

Half-Life

5-7 minutes (extremely short, rapidly degraded by proteases)

Typical Dose

100–400 mcg

Frequency

Immediately post-workout, bilaterally into trained muscle groups

Cycle Length

4-5 weeks

Administration Routes:

intramuscular

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Research Summary

Preclinical

MGF was discovered by Dr. Geoffrey Goldspink's group at University College London. Research demonstrated that mechanical overload induces MGF expression as the initial IGF-1 splice variant before shifting to IGF-1Ea (systemic). Animal studies show MGF administration increases muscle mass by 20% within weeks. The extremely short half-life of the synthetic peptide limits practical use, leading to the development of PEG-MGF for extended activity.