What is the half-life of MK-677 (Ibutamoren)?

MK-677 (Ibutamoren) has a half-life of 24 hours, which is why it's typically administered once daily for optimal therapeutic effect.

How do I reconstitute MK-677 (Ibutamoren)?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Growth Hormone

Phase 2

MK-677 (Ibutamoren)

Also known as: MK-677, Ibutamoren, MK-0677, L-163, 191, Nutrobal

Overview

Key Facts

Primary Goal: An orally active, non-peptide growth hormone secretagogue that mimics ghrelin signaling to increase GH and IGF-1 levels

An orally active, non-peptide growth hormone secretagogue that mimics ghrelin signaling to increase GH and IGF-1 levels. Though technically not a peptide, it is commonly grouped with GH peptides due to its mechanism and widespread use in the research community. Half-Life 24 hours Typical Dose 10–25 mg Frequency once daily Cycle Length 8-16 weeks (some research protocols extend longer)

Dosing Information

Half-Life

24 hours

Typical Dose

10–25 mg

Frequency

once daily

Cycle Length

8-16 weeks (some research protocols extend longer)

Administration Routes:

oral

Storage & Reconstitution

Unreconstituted (Powder)

Temperature15–25°C (59–77°F)

DurationUp to 3 months

Reconstituted (Mixed)

Temperature15–25°C (59–77°F)

Duration2-4 weeks

Research Summary

Phase 2

MK-677 has been studied in multiple Phase II trials for muscle wasting, osteoporosis, and GH deficiency. A landmark 2-year study in elderly adults demonstrated sustained increases in GH and IGF-1 without tachyphylaxis, along with improved lean mass. However, concerns about insulin resistance and glucose metabolism have prevented FDA approval to date.