What is the half-life of NA-Selank?

NA-Selank has a half-life of ~20-60 minutes (extended over parent Selank), which is why it's typically administered 1-2 times daily for optimal therapeutic effect.

How do I reconstitute NA-Selank?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Healing & Recovery

Preclinical

NA-Selank

Also known as: N-Acetyl Selank, Acetylated Selank, NA-Selank Amidate

Overview

Key Facts

Primary Goal: An acetylated analog of Selank with improved metabolic stability and enhanced blood-brain barrier penetration compared to the parent peptide

An acetylated analog of Selank with improved metabolic stability and enhanced blood-brain barrier penetration compared to the parent peptide. The N-acetyl modification protects against aminopeptidase degradation, extending its effective duration of action and potentially increasing central nervous system bioavailability. Half-Life ~20-60 minutes (extended over parent Selank) Typical Dose 100–400 mcg Frequency 1-2 times daily Cycle Length 14-30 days

Dosing Information

Half-Life

~20-60 minutes (extended over parent Selank)

Typical Dose

100–400 mcg

Frequency

1-2 times daily

Cycle Length

14-30 days

Administration Routes:

subcutaneous

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Note: Protect from light. Do not freeze reconstituted solution.

Research Summary

Preclinical

NA-Selank is a pharmacokinetically optimized derivative of Selank designed to overcome the rapid enzymatic degradation that limits the parent peptide's duration of action. While standard Selank has extensive Russian clinical data, the acetylated form has been studied primarily in in vitro and preclinical settings. Research confirms the N-acetyl modification significantly extends the peptide's plasma half-life while preserving its anxiolytic and immunomodulatory pharmacology. It is widely used in research communities as an enhanced-stability alternative to Selank.