What is the half-life of NA-Semax?

NA-Semax has a half-life of ~20-60 minutes (extended over parent Semax), which is why it's typically administered 1-2 times daily for optimal therapeutic effect.

How do I reconstitute NA-Semax?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Healing & Recovery

Preclinical

NA-Semax

Also known as: N-Acetyl Semax, Acetylated Semax, NA-Semax Amidate

Overview

Key Facts

Primary Goal: An acetylated analog of Semax with enhanced metabolic stability and reportedly greater potency in promoting BDNF expression

An acetylated analog of Semax with enhanced metabolic stability and reportedly greater potency in promoting BDNF expression. The N-acetyl modification reduces susceptibility to aminopeptidase cleavage, extending the peptide's active duration and potentially amplifying its neurotrophic effects. Half-Life ~20-60 minutes (extended over parent Semax) Typical Dose 100–600 mcg Frequency 1-2 times daily Cycle Length 10-30 days

Dosing Information

Half-Life

~20-60 minutes (extended over parent Semax)

Typical Dose

100–600 mcg

Frequency

1-2 times daily

Cycle Length

10-30 days

Administration Routes:

subcutaneous

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Note: Protect from light. Do not freeze reconstituted solution.

Research Summary

Preclinical

NA-Semax builds on the extensive Russian clinical research behind standard Semax by incorporating an N-acetyl modification for improved pharmacokinetics. Preclinical studies suggest that the acetylated form may produce greater BDNF elevation per dose compared to unmodified Semax. While it lacks the independent clinical trial data of its parent compound, the pharmacological rationale for the modification is well-established, and it has become one of the most popular nootropic peptides in research communities seeking enhanced potency over standard Semax.