What is the half-life of Palmitoyl Pentapeptide-4?

Palmitoyl Pentapeptide-4 has a half-life of ~4-6 hours (topical bioactivity window), which is why it's typically administered Twice daily (topical application) for optimal therapeutic effect.

How do I reconstitute Palmitoyl Pentapeptide-4?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Healing & Recovery

Preclinical

Palmitoyl Pentapeptide-4

Also known as: Matrixyl, Pal-KTTKS, Palmitoyl-Lys-Thr-Thr-Lys-Ser

Overview

Key Facts

Primary Goal: A lipopeptide consisting of a palmitoyl group attached to the pentapeptide KTTKS, a fragment of type I procollagen

A lipopeptide consisting of a palmitoyl group attached to the pentapeptide KTTKS, a fragment of type I procollagen. Branded as Matrixyl, it is one of the most commercially successful cosmetic peptides, clinically shown to stimulate collagen synthesis and reduce wrinkle depth. The palmitoyl group enhances skin penetration by increasing lipophilicity. Half-Life ~4-6 hours (topical bioactivity window) Typical Dose 2–8 mg Frequency Twice daily (topical application) Cycle Length Continuous daily use; results typically visible after 8-12 weeks

Dosing Information

Half-Life

~4-6 hours (topical bioactivity window)

Typical Dose

2–8 mg

Frequency

Twice daily (topical application)

Cycle Length

Continuous daily use; results typically visible after 8-12 weeks

Administration Routes:

topical

Storage & Reconstitution

Unreconstituted (Powder)

Temperature15–25°C (59–77°F)

DurationUp to 3 months

Reconstituted (Mixed)

Temperature15–25°C (59–77°F)

Duration2-4 weeks

Research Summary

Preclinical

Developed by Sederma (now part of Croda), Matrixyl was introduced in 2000 and became one of the first clinically validated cosmetic peptides. A landmark double-blind study demonstrated that 8 weeks of topical application reduced wrinkle volume by 36% and wrinkle depth by 27% compared to placebo. Subsequent studies confirmed collagen synthesis stimulation in ex vivo human skin models. It remains one of the best-studied and most widely used peptides in anti-aging skincare.