What is the half-life of Selank?

Selank has a half-life of ~3-5 minutes (native); active metabolites persist for several hours, which is why it's typically administered 1-3 times daily; evening dose for sleep support for optimal therapeutic effect.

How do I reconstitute Selank?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Healing & Recovery

Phase 3

Selank

Also known as: Selank, TP-7, Selanc

Overview

Key Facts

Primary Goal: A synthetic analog of the naturally occurring immunomodulatory peptide tuftsin, developed at the Institute of Molecular Genetics of the Russian Academy of Sciences

A synthetic analog of the naturally occurring immunomodulatory peptide tuftsin, developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. Selank is primarily recognized as an anxiolytic and nootropic peptide, but its relevance to sleep lies in its potent anti-anxiety effects and modulation of GABAergic neurotransmission. By reducing anxiety and normalizing stress responses without sedation, Selank helps resolve the anxiety-driven insomnia that affects a large proportion of sleep disorder patients. Half-Life ~3-5 minutes (native); active metabolites persist for several hours Typical Dose 250–750 mcg Frequency 1-3 times daily; evening dose for sleep support Cycle Length 2-4 weeks on, 2 weeks off

Dosing Information

Half-Life

~3-5 minutes (native); active metabolites persist for several hours

Typical Dose

250–750 mcg

Frequency

1-3 times daily; evening dose for sleep support

Cycle Length

2-4 weeks on, 2 weeks off

Administration Routes:

subcutaneous

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F)

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Research Summary

Phase 3

Selank has been approved in Russia as an anxiolytic medication (nasal spray formulation) and has been studied in over 30 clinical and preclinical trials. Studies demonstrated anxiolytic effects comparable to benzodiazepines but without sedation, cognitive impairment, or dependence. Zozulia et al. showed that Selank normalized the sleep-wake cycle in patients with generalized anxiety disorder, with improvements in both sleep onset latency and sleep maintenance. Gene expression studies revealed modulation of 45 genes related to GABAergic and serotonergic neurotransmission. Its dual anxiolytic-nootropic profile makes it particularly valuable for individuals whose sleep disturbance stems from anxiety or cognitive hyperarousal.